===============================
R CMD BUILD
===============================
* checking for file ‘EpiMix/DESCRIPTION’ ... OK
* preparing ‘EpiMix’:
* checking DESCRIPTION meta-information ... OK
* installing the package to build vignettes
* creating vignettes ... ERROR
duplicated vignette title:
‘vignette’
--- re-building ‘EpiMix_demo.Rmd’ using rmarkdown
Loading required package: EpiMix.data
Loading required package: ExperimentHub
Loading required package: BiocGenerics
Attaching package: 'BiocGenerics'
The following objects are masked from 'package:stats':
IQR, mad, sd, var, xtabs
The following objects are masked from 'package:base':
Filter, Find, Map, Position, Reduce, anyDuplicated, append,
as.data.frame, basename, cbind, colnames, dirname, do.call,
duplicated, eval, evalq, get, grep, grepl, intersect, is.unsorted,
lapply, mapply, match, mget, order, paste, pmax, pmax.int, pmin,
pmin.int, rank, rbind, rownames, sapply, setdiff, sort, table,
tapply, union, unique, unsplit, which.max, which.min
Loading required package: AnnotationHub
Loading required package: BiocFileCache
Loading required package: dbplyr
Setting options('download.file.method.GEOquery'='auto')
Setting options('GEOquery.inmemory.gpl'=FALSE)
snapshotDate(): 2022-04-26
see ?sesameData and browseVignettes('sesameData') for documentation
loading from cache
require("GenomicRanges")
Warning: executing %dopar% sequentially: no parallel backend registered
snapshotDate(): 2022-04-26
see ?sesameData and browseVignettes('sesameData') for documentation
loading from cache
trying URL 'https://egg2.wustl.edu/roadmap/data/byFileType/chromhmmSegmentations/ChmmModels/core_K27ac/jointModel/final/E096_18_core_K27ac_hg38lift_mnemonics.bed.gz'
Content type 'application/x-gzip' length 3835377 bytes (3.7 MB)
==================================================
downloaded 3.7 MB
snapshotDate(): 2022-04-26
see ?sesameData and browseVignettes('sesameData') for documentation
loading from cache
Returning distal probes: 160862
Searching for the 20 near genes
Identifying gene position for each probe
Warning in getRandomGenes(target.probe = target.probe, gene.expression.data = gene.expression.data, :
There is not enough genes to generate 1000 permutations. Using 805 random genes instead.
Warning in getRandomGenes(target.probe = target.probe, gene.expression.data = gene.expression.data, :
There is not enough genes to generate 1000 permutations. Using 793 random genes instead.
Warning in getRandomGenes(target.probe = target.probe, gene.expression.data = gene.expression.data, :
There is not enough genes to generate 1000 permutations. Using 798 random genes instead.
trying URL 'http://gdac.broadinstitute.org/runs/stddata__latest/data/OV/20160128/gdac.broadinstitute.org_OV.Merge_methylation__humanmethylation27__jhu_usc_edu__Level_3__within_bioassay_data_set_function__data.Level_3.2016012800.0.0.tar.gz'
Content type 'application/x-gzip' length 152968396 bytes (145.9 MB)
==================================================
downloaded 145.9 MB
trying URL 'http://gdac.broadinstitute.org/runs/stddata__latest/data/OV/20160128/gdac.broadinstitute.org_OV.Merge_methylation__humanmethylation450__jhu_usc_edu__Level_3__within_bioassay_data_set_function__data.Level_3.2016012800.0.0.tar.gz'
Content type 'application/x-gzip' length 51525820 bytes (49.1 MB)
==================================================
downloaded 49.1 MB
trying URL 'http://gdac.broadinstitute.org/runs/stddata__latest/data/OV/20160128/gdac.broadinstitute.org_OV.Merge_transcriptome__agilentg4502a_07_3__unc_edu__Level_3__unc_lowess_normalization_gene_level__data.Level_3.2016012800.0.0.tar.gz'
Content type 'application/x-gzip' length 36996192 bytes (35.3 MB)
==================================================
downloaded 35.3 MB
trying URL 'http://gdac.broadinstitute.org/runs/stddata__latest/data/OV/20160128/gdac.broadinstitute.org_OV.miRseq_Preprocess.Level_3.2016012800.0.0.tar.gz'
Content type 'application/x-gzip' length 2663096 bytes (2.5 MB)
==================================================
downloaded 2.5 MB
snapshotDate(): 2022-04-26
see ?EpiMix.data and browseVignettes('EpiMix.data') for documentation
loading from cache
`geom_smooth()` using formula 'y ~ x'
Loading required package: regioneR
Loading required package: GenomicFeatures
Loading required package: AnnotationDbi
Loading required package: Biobase
Welcome to Bioconductor
Vignettes contain introductory material; view with
'browseVignettes()'. To cite Bioconductor, see
'citation("Biobase")', and for packages 'citation("pkgname")'.
Attaching package: 'Biobase'
The following object is masked from 'package:ExperimentHub':
cache
The following object is masked from 'package:AnnotationHub':
cache
snapshotDate(): 2022-04-26
see ?sesameData and browseVignettes('sesameData') for documentation
loading from cache
403 genes were dropped because they have exons located on both strands
of the same reference sequence or on more than one reference sequence,
so cannot be represented by a single genomic range.
Use 'single.strand.genes.only=FALSE' to get all the genes in a
GRangesList object, or use suppressMessages() to suppress this message.
'select()' returned 1:1 mapping between keys and columns
Warning in text.default(x = 0.281994261119082, y = c(chr12 = 95.7895435628561), :
"offest" is not a graphical parameter
Warning in doTryCatch(return(expr), name, parentenv, handler) :
"offest" is not a graphical parameter
snapshotDate(): 2022-04-26
see ?sesameData and browseVignettes('sesameData') for documentation
loading from cache
Searching for the 10 near genes
Identifying gene position for each probe
clusterProfiler v4.4.1 For help: https://yulab-smu.top/biomedical-knowledge-mining-book/
If you use clusterProfiler in published research, please cite:
T Wu, E Hu, S Xu, M Chen, P Guo, Z Dai, T Feng, L Zhou, W Tang, L Zhan, X Fu, S Liu, X Bo, and G Yu. clusterProfiler 4.0: A universal enrichment tool for interpreting omics data. The Innovation. 2021, 2(3):100141
Attaching package: 'clusterProfiler'
The following object is masked from 'package:AnnotationDbi':
select
The following object is masked from 'package:IRanges':
slice
The following object is masked from 'package:S4Vectors':
rename
The following object is masked from 'package:stats':
filter
'select()' returned 1:1 mapping between keys and columns
'select()' returned 1:1 mapping between keys and columns
Reading KEGG annotation online:
Reading KEGG annotation online:
trying URL 'http://gdac.broadinstitute.org/runs/stddata__latest/data/LUAD/20160128/gdac.broadinstitute.org_LUAD.Merge_Clinical.Level_1.2016012800.0.0.tar.gz'
Content type 'application/x-gzip' length 1777018 bytes (1.7 MB)
==================================================
downloaded 1.7 MB
Loading required package: ggplot2
Loading required package: ggpubr
Attaching package: 'survminer'
The following object is masked from 'package:survival':
myeloma
trying URL 'http://gdac.broadinstitute.org/runs/stddata__latest/data/LUAD/20160128/gdac.broadinstitute.org_LUAD.Merge_Clinical.Level_1.2016012800.0.0.tar.gz'
Content type 'application/x-gzip' length 1777018 bytes (1.7 MB)
==================================================
downloaded 1.7 MB
--- finished re-building ‘EpiMix_demo.Rmd’
--- re-building ‘overview.Rmd’ using rmarkdown
snapshotDate(): 2022-04-26
see ?sesameData and browseVignettes('sesameData') for documentation
loading from cache
trying URL 'http://gdac.broadinstitute.org/runs/stddata__latest/data/OV/20160128/gdac.broadinstitute.org_OV.Merge_methylation__humanmethylation27__jhu_usc_edu__Level_3__within_bioassay_data_set_function__data.Level_3.2016012800.0.0.tar.gz'
Content type 'application/x-gzip' length 152968396 bytes (145.9 MB)
==================================================
downloaded 145.9 MB
trying URL 'http://gdac.broadinstitute.org/runs/stddata__latest/data/OV/20160128/gdac.broadinstitute.org_OV.Merge_methylation__humanmethylation450__jhu_usc_edu__Level_3__within_bioassay_data_set_function__data.Level_3.2016012800.0.0.tar.gz'
Content type 'application/x-gzip' length 51525820 bytes (49.1 MB)
==================================================
downloaded 49.1 MB
snapshotDate(): 2022-04-26
see ?sesameData and browseVignettes('sesameData') for documentation
loading from cache
403 genes were dropped because they have exons located on both strands
of the same reference sequence or on more than one reference sequence,
so cannot be represented by a single genomic range.
Use 'single.strand.genes.only=FALSE' to get all the genes in a
GRangesList object, or use suppressMessages() to suppress this message.
'select()' returned 1:1 mapping between keys and columns
Warning in text.default(x = 0.281994261119082, y = c(chr12 = 95.7895435628561), :
"offest" is not a graphical parameter
Warning in doTryCatch(return(expr), name, parentenv, handler) :
"offest" is not a graphical parameter
snapshotDate(): 2022-04-26
see ?sesameData and browseVignettes('sesameData') for documentation
loading from cache
Searching for the 10 near genes
Identifying gene position for each probe
Quitting from lines 560-585 (overview.Rmd)
Error: processing vignette 'overview.Rmd' failed with diagnostics:
could not find function "function.enrich"
--- failed re-building ‘overview.Rmd’
SUMMARY: processing the following file failed:
‘overview.Rmd’
Error: Vignette re-building failed.
Error: Duplicate vignette titles.
Ensure that the %\VignetteIndexEntry lines in the vignette sources
correspond to the vignette titles.
Execution halted
===============================
R CMD BUILD
===============================
* checking for file ‘EpiMix/DESCRIPTION’ ... OK
* preparing ‘EpiMix’:
* checking DESCRIPTION meta-information ... OK
* installing the package to build vignettes
* creating vignettes ... ERROR
duplicated vignette title:
‘vignette’
--- re-building ‘EpiMix_demo.Rmd’ using rmarkdown
Loading required package: EpiMix.data
Loading required package: ExperimentHub
Loading required package: BiocGenerics
Attaching package: 'BiocGenerics'
The following objects are masked from 'package:stats':
IQR, mad, sd, var, xtabs
The following objects are masked from 'package:base':
Filter, Find, Map, Position, Reduce, anyDuplicated, append,
as.data.frame, basename, cbind, colnames, dirname, do.call,
duplicated, eval, evalq, get, grep, grepl, intersect, is.unsorted,
lapply, mapply, match, mget, order, paste, pmax, pmax.int, pmin,
pmin.int, rank, rbind, rownames, sapply, setdiff, sort, table,
tapply, union, unique, unsplit, which.max, which.min
Loading required package: AnnotationHub
Loading required package: BiocFileCache
Loading required package: dbplyr
Setting options('download.file.method.GEOquery'='auto')
Setting options('GEOquery.inmemory.gpl'=FALSE)
snapshotDate(): 2022-04-26
see ?sesameData and browseVignettes('sesameData') for documentation
loading from cache
require("GenomicRanges")
Warning: executing %dopar% sequentially: no parallel backend registered
snapshotDate(): 2022-04-26
see ?sesameData and browseVignettes('sesameData') for documentation
loading from cache
trying URL 'https://egg2.wustl.edu/roadmap/data/byFileType/chromhmmSegmentations/ChmmModels/core_K27ac/jointModel/final/E096_18_core_K27ac_hg38lift_mnemonics.bed.gz'
Content type 'application/x-gzip' length 3835377 bytes (3.7 MB)
==================================================
downloaded 3.7 MB
snapshotDate(): 2022-04-26
see ?sesameData and browseVignettes('sesameData') for documentation
loading from cache
Returning distal probes: 160862
Searching for the 20 near genes
Identifying gene position for each probe
Warning in getRandomGenes(target.probe = target.probe, gene.expression.data = gene.expression.data, :
There is not enough genes to generate 1000 permutations. Using 805 random genes instead.
Warning in getRandomGenes(target.probe = target.probe, gene.expression.data = gene.expression.data, :
There is not enough genes to generate 1000 permutations. Using 793 random genes instead.
Warning in getRandomGenes(target.probe = target.probe, gene.expression.data = gene.expression.data, :
There is not enough genes to generate 1000 permutations. Using 798 random genes instead.
trying URL 'http://gdac.broadinstitute.org/runs/stddata__latest/data/OV/20160128/gdac.broadinstitute.org_OV.Merge_methylation__humanmethylation27__jhu_usc_edu__Level_3__within_bioassay_data_set_function__data.Level_3.2016012800.0.0.tar.gz'
Content type 'application/x-gzip' length 152968396 bytes (145.9 MB)
==================================================
downloaded 145.9 MB
trying URL 'http://gdac.broadinstitute.org/runs/stddata__latest/data/OV/20160128/gdac.broadinstitute.org_OV.Merge_methylation__humanmethylation450__jhu_usc_edu__Level_3__within_bioassay_data_set_function__data.Level_3.2016012800.0.0.tar.gz'
Content type 'application/x-gzip' length 51525820 bytes (49.1 MB)
==================================================
downloaded 49.1 MB
trying URL 'http://gdac.broadinstitute.org/runs/stddata__latest/data/OV/20160128/gdac.broadinstitute.org_OV.Merge_transcriptome__agilentg4502a_07_3__unc_edu__Level_3__unc_lowess_normalization_gene_level__data.Level_3.2016012800.0.0.tar.gz'
Content type 'application/x-gzip' length 36996192 bytes (35.3 MB)
==================================================
downloaded 35.3 MB
trying URL 'http://gdac.broadinstitute.org/runs/stddata__latest/data/OV/20160128/gdac.broadinstitute.org_OV.miRseq_Preprocess.Level_3.2016012800.0.0.tar.gz'
Content type 'application/x-gzip' length 2663096 bytes (2.5 MB)
==================================================
downloaded 2.5 MB
snapshotDate(): 2022-04-26
see ?EpiMix.data and browseVignettes('EpiMix.data') for documentation
loading from cache
Fontconfig warning: ignoring UTF-8: not a valid region tag
`geom_smooth()` using formula 'y ~ x'
Loading required package: regioneR
Loading required package: GenomicFeatures
Loading required package: AnnotationDbi
Loading required package: Biobase
Welcome to Bioconductor
Vignettes contain introductory material; view with
'browseVignettes()'. To cite Bioconductor, see
'citation("Biobase")', and for packages 'citation("pkgname")'.
Attaching package: 'Biobase'
The following object is masked from 'package:ExperimentHub':
cache
The following object is masked from 'package:AnnotationHub':
cache
snapshotDate(): 2022-04-26
see ?sesameData and browseVignettes('sesameData') for documentation
loading from cache
403 genes were dropped because they have exons located on both strands
of the same reference sequence or on more than one reference sequence,
so cannot be represented by a single genomic range.
Use 'single.strand.genes.only=FALSE' to get all the genes in a
GRangesList object, or use suppressMessages() to suppress this message.
'select()' returned 1:1 mapping between keys and columns
Warning in text.default(x = 0.281994261119082, y = c(chr12 = 95.7895435628561), :
"offest" is not a graphical parameter
Warning in doTryCatch(return(expr), name, parentenv, handler) :
"offest" is not a graphical parameter
snapshotDate(): 2022-04-26
see ?sesameData and browseVignettes('sesameData') for documentation
loading from cache
Searching for the 10 near genes
Identifying gene position for each probe
clusterProfiler v4.4.1 For help: https://yulab-smu.top/biomedical-knowledge-mining-book/
If you use clusterProfiler in published research, please cite:
T Wu, E Hu, S Xu, M Chen, P Guo, Z Dai, T Feng, L Zhou, W Tang, L Zhan, X Fu, S Liu, X Bo, and G Yu. clusterProfiler 4.0: A universal enrichment tool for interpreting omics data. The Innovation. 2021, 2(3):100141
Attaching package: 'clusterProfiler'
The following object is masked from 'package:AnnotationDbi':
select
The following object is masked from 'package:IRanges':
slice
The following object is masked from 'package:S4Vectors':
rename
The following object is masked from 'package:stats':
filter
'select()' returned 1:1 mapping between keys and columns
'select()' returned 1:1 mapping between keys and columns
Reading KEGG annotation online:
Reading KEGG annotation online:
trying URL 'http://gdac.broadinstitute.org/runs/stddata__latest/data/LUAD/20160128/gdac.broadinstitute.org_LUAD.Merge_Clinical.Level_1.2016012800.0.0.tar.gz'
Content type 'application/x-gzip' length 1777018 bytes (1.7 MB)
==================================================
downloaded 1.7 MB
Loading required package: ggplot2
Loading required package: ggpubr
Attaching package: 'survminer'
The following object is masked from 'package:survival':
myeloma
trying URL 'http://gdac.broadinstitute.org/runs/stddata__latest/data/LUAD/20160128/gdac.broadinstitute.org_LUAD.Merge_Clinical.Level_1.2016012800.0.0.tar.gz'
Content type 'application/x-gzip' length 1777018 bytes (1.7 MB)
==================================================
downloaded 1.7 MB
Quitting from lines 558-559 (EpiMix_demo.Rmd)
Error: processing vignette 'EpiMix_demo.Rmd' failed with diagnostics:
$ operator is invalid for atomic vectors
--- failed re-building ‘EpiMix_demo.Rmd’
--- re-building ‘overview.Rmd’ using rmarkdown
snapshotDate(): 2022-04-26
see ?sesameData and browseVignettes('sesameData') for documentation
loading from cache
trying URL 'http://gdac.broadinstitute.org/runs/stddata__latest/data/OV/20160128/gdac.broadinstitute.org_OV.Merge_methylation__humanmethylation27__jhu_usc_edu__Level_3__within_bioassay_data_set_function__data.Level_3.2016012800.0.0.tar.gz'
Content type 'application/x-gzip' length 152968396 bytes (145.9 MB)
==================================================
downloaded 145.9 MB
trying URL 'http://gdac.broadinstitute.org/runs/stddata__latest/data/OV/20160128/gdac.broadinstitute.org_OV.Merge_methylation__humanmethylation450__jhu_usc_edu__Level_3__within_bioassay_data_set_function__data.Level_3.2016012800.0.0.tar.gz'
Content type 'application/x-gzip' length 51525820 bytes (49.1 MB)
==================================================
downloaded 49.1 MB
snapshotDate(): 2022-04-26
see ?sesameData and browseVignettes('sesameData') for documentation
loading from cache
403 genes were dropped because they have exons located on both strands
of the same reference sequence or on more than one reference sequence,
so cannot be represented by a single genomic range.
Use 'single.strand.genes.only=FALSE' to get all the genes in a
GRangesList object, or use suppressMessages() to suppress this message.
'select()' returned 1:1 mapping between keys and columns
Warning in text.default(x = 0.281994261119082, y = c(chr12 = 95.7895435628561), :
"offest" is not a graphical parameter
Warning in doTryCatch(return(expr), name, parentenv, handler) :
"offest" is not a graphical parameter
snapshotDate(): 2022-04-26
see ?sesameData and browseVignettes('sesameData') for documentation
loading from cache
Searching for the 10 near genes
Identifying gene position for each probe
Quitting from lines 560-585 (overview.Rmd)
Error: processing vignette 'overview.Rmd' failed with diagnostics:
could not find function "function.enrich"
--- failed re-building ‘overview.Rmd’
SUMMARY: processing the following files failed:
‘EpiMix_demo.Rmd’ ‘overview.Rmd’
Error: Vignette re-building failed.
Error: Duplicate vignette titles.
Ensure that the %\VignetteIndexEntry lines in the vignette sources
correspond to the vignette titles.
Execution halted